Ifosfamide may lower your bodys resistance and there is a chance you might get the infection the immunization is meant to prevent. Case reports of subacute interstitial pneumonias can be found in the literature, although the responsibility of ifosfamide remains unclear, as it was used in. Ifosfamide is a newly available analog of cyclophosphamide in the oxazaphosphorine drug class. Data sources include ibm watson micromedex updated 28 feb 2020, cerner multum updated 2 mar 2020. For treating sarcomas, testicular cancer lymphoma or other types of cancers. There is a black box warning for this drug as shown here. Insert pdf file content into a powerpoint presentation powerpoint.
We studied this regimen in adult and adolescent patients with bone and soft tissue sarcomas. Definition from the nci drug dictionary detailed scientific definition and other names for this drug. Mesnex is indicated as a prophylactic agent in reducing. Ifosfamide, like cyclophosphamide, is an oxazophosphorine. Although ifosfamide has been substituted for cyclophosphamide in many therapeutic regimens, it has not been proven superior to cyclophosphamide in any cancer. Each 20 mg vial contains 20 mg idarubicin hydrochloride, usp and 200 mg of lactose nf hydrous as an orangered, lyophilized powder. Ifex ifosfamide for injection, usp singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. Ifosfamide, like cyclophosphamide, is an oxazophosphorine alkylating agent. Cyclophosphamide has been marketed for 32 years, and it remains a highly effective agent for a. Ifosfamide mustard significantly decreased the growth of both cancer cell lines in a dosedependent manner p. Find patient medical information for ifosfamidemesna intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Guidelines for the administration of mesna with ifosfamide.
Ifosfamide is a parenterally administered alkylating agent similar to cyclophosphamide that is used in the treatment of several forms of cancer including lymphomas, sarcoma and advanced forms of solid organ cancer such as breast, testicular, ovarian, gastric and lung cancer. Ifosfamide also marketed as ifex is a nitrogen mustard alkylating agent used in the treatment of cancerin vitro. Mesnex tablets are given orally in a dosage equal to 40% of the ifosfamide dose 2 and 6 hours after each dose of ifosfamide. The usual recommended dosage of ifosfamide for treating testicular cancer is 1.
Apr 25, 2008 ifosfamide is an antineoplastic agent useful in the treatment of a wide range of cancers including sarcomas, gynecologic cancers, lymphoma and testicular cancers. Review of advances in uroprotective agents for cyclophosphamide. Mesnex injection is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage ww at the time of ifosfamide administration. However, as this emedtv segment explains, your ifosfamide dosage will be calculated using your weight, height, and other medical conditions, among other factors. Methylene blue reversal of ifosfamiderelated encephalopathy. Voorma, ingevolge het besluit van het college voor promoties. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. The high incidence of this toxicity requires uroprotection with aggressive hydration, frequent bladder emptying, and the concurrent use of mesna, a uroprotective agent. Ifosfamide is given intravenously by iv usually once a day for five days every three weeks. Ifosfamide side effects, dosage, interactions drugs everyday health search. Also, avoid persons who have taken oral polio vaccine within the. Ifex ifosfamide dosing, indications, interactions, adverse. Ifex ifosfamide side effects, images, uses, dosage. Encephalopathy is a potentially fatal toxicity of ifosfamide.
These may be responsible for the toxicity of the drug. Myelosuppression, neurotoxicity, and urotoxicity see full prescribing information for complete boxed warning. Insert pdf content into your presentation either as a picture that shows on your slide, or as a document that you can open during your slide show. Ifosfamide is also being studied in the treatment of other types of cancer. Use the quantity of diluent shown below to constitute the product. Aprepitantifosfamideencephalopathydrug interaction. Mesnex injection is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage weight by weight ww at the time of ifosfamide administration and 4 and 8 hours after each dose of ifosfamide.
Ifosfamide has a similar spectrum of antitumor activity but has different pharmacokinetics that could provide advantages in efficacy. Dailymed ifex ifosfamide injection, powder, for solution. Ifosfamide for injection ifosfamide for injection, usp singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. Mesna equivalent of 40% total daily ifosfamide dose given as iv bolus postifosfamide mesna equivalent of 40% total daily ifosfamide dose given orally 2 and 6 hours after the end of the ifosfamide infusion. Grapefruit may interact with ifosfamide and lead to unwanted side effects. Ifosfamide neurotoxicity may become manifest within a few hours to a few days after first administration and in most cases resolves within 48 to 72 hours of ifosfamide discontinuation. Several payment sources exist for cancer drugs in ontario, depending on the drug, disease indication, and how and where it is delivered. Please click here for important safety information, including boxed warning regarding hepatic impairment, and click here 2 for full prescribing information. Ifex ifosfamide dose, indications, adverse effects.
See actual entry in rtecs for complete information. Jul 01, 2019 discontinue ifosfamide or reduce dosage in patients who develop hematuria 50 erythrocyteshpf while receiving usual dosages of ifosfamide in conjunction with mesna. Oct 24, 2016 ifosfamide should only be administered when there are facilities for regular monitoring of clinical, biochemical and haematological parameters before, during and after administration and under the direction of a specialist oncology service by physicians experienced with this drug. Only select registry of toxic effects of chemical substances rtecs data is presented here. Prior to constituting ixempra for injection, the kit should be removed from the refrigerator and allowed to stand at room temperature for approximately 30 minutes. Supportive therapy should be maintained until their complete resolution. Ifosfamide is an anticancer antineoplastic or cytotoxic chemotherapy drug. Ifosfamide should only be administered when there are facilities for regular monitoring of clinical, biochemical and haematological parameters before, during and after administration and under the direction of a specialist oncology service by physicians experienced with this drug. Zinecard is a cytoprotective agent indicated for reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin dose of 300 mgm 2 and who will continue to receive doxorubicin therapy to maintain tumor control. If youre a patient at msk and you need to reach a provider after 5. Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. Although ifosfamide has several significant toxic effects, the doselimiting toxicity is hemorrhagic cystitis. This drug may lower the ability of the bone marrow to make blood cells that the body needs.
A randomized clinical trial of adjuvant chemotherapy with. Case reports of subacute interstitial pneumonias can be found in the literature, although the responsibility of ifosfamide remains unclear, as it. Ifosfamide belongs to the category of mustard gas derivatives. Carcinogenesis and mutagenesis treatment with ifosfamide involves the risk of secondary tumors and their precursors as late sequelae. Ifosfamide is a cancer medication that interferes with the growth and spread of cancer cells in the body. Aug, 2018 drinking alcohol can increase certain side effects of ifosfamide, especially nausea and vomiting. Myelosuppression can be severe and lead to fatal infections 5. Ifosfamide is a synthetic structural isomer of cyclophosphamide that has been approved for concurrent use with other drugs usually cisplatin, etoposide, or vinblastine in the treatment of metastatic germcell testicular cancer and some especially pediatric sarcomas. Alkylating agents are most active in the resting phase of the cell. Risk factors for the development of cns toxicity include the following.
Ifosfamide ifo, sold under the brand name ifex among others, is a chemotherapy medication used to treat a number of types of cancer. Reduce bladder toxicity with conventional uroprophylaxis e. Clinical manifestations of encephalopathy range from fatigue and confusion to coma. Common adverse reactions include alopecia, nausea and vomiting, leukopenia, anemia, cns toxicity. Ifosfamide has a broad spectrum of antineoplastic activity. We have confirmed reports of activity in patients previously treated with ifosfamide.
Stability of ifosfamide in solutions for multiday infusion b. This includes testicular cancer, soft tissue sarcoma, osteosarcoma, bladder cancer, small cell lung cancer, cervical cancer, and ovarian cancer. Clinical pharmacology of ifosfamide and metabolites. If you have any questions, contact a member of your healthcare team directly. Ifosfamide intravenous route precautions mayo clinic. Ifosfamide mustard significantly decreased the growth of both cancer cell lines in a dosedependent manner p ifosfamide solution for injection drug summary. The total daily dose of mesnex is 60% of the ifosfamide dose. Common adverse reactions include alopecia, nausea and vomiting, leukopenia, anemia, cns toxicity, hematuria, and infection. Variations, taking into account individual circumstances, may. By continuing to browse this site you are agreeing to our use of cookies. Store intact vials at room temp or under refrigeration.
The recommended dosing schedule is outlined below in table 1. A new method to quantify ifosfamide blood levels using dried. Mesnex is indicated as a prophylactic agent in reducing the. Dosage may be reduced, delayed or discontinued in patients with bone marrow. The total daily dose of mesnex is 100% of the ifosfamide dose. One patient developed severe encephalopathy at day 6 total dose 18 g ifosfamide with complete recovery after cessation of the infusion. Export all images to powerpoint file add to my favorites. Ifosfamide side effects, dosage, interactions drugs. Ifosfamide injection 1g summary of product characteristics. Physical and chemical stability of highdose ifosfamide and mesna for prolonged 14day continuous infusion article pdf available in journal of oncology pharmacy practice 201 march 20 with. For certain toxicities, an initial dose reduction of 20% should be made, followed by an additional. Additional 20% dose reduction if toxicities recur 25 mgm2 iv over 3 hours every 3 weeks. Ifosfamide investigated as a drug, mutagen, reproductive effector, and tumorigen.
Ifosfamide can cause severe neurotoxicity resulting in encephalopathy and death. Ifosfamide, carboplatin and etoposide in children with poorrisk. You may be able to overcome this with stronger flavored herbs such as basil, sage, or thyme. Ifosfamide also marketed as ifex is a nitrogen mustard alkylating agent used in the treatment of cancer in vitro. Drinking alcohol can increase certain side effects of ifosfamide, especially nausea and vomiting. Save money on your ifosfamide injection prescription by switching to tevas fdaapproved generic version. In addition, other persons living in your house should not take oral polio vaccine since there is a chance they could pass the polio virus on to you. Ifex ifosfamide for injection, intravenous use warning. Ifosfamide neurotoxicity and potential treatment with.
The number of anomalies was also significantly increased over the. Ifosfamide is only found in individuals that have used or taken this drug. Medlineplus information on ifosfamide a lay language summary of important information about this drug that may include the following. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Do not receive a live vaccine while using ifosfamide, or you could develop a serious infection. It is a positional isomer of cyclophosphamide which is active as an alkylating agent and an immunosuppressive agent. Ifex ifosfamide for injection singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide.
Each of the above chemotherapy agents ifosfamide, etoposide and carboplatin has been. In the adult population, retrospective series demonstrate promise in patients and even in patients previously treated with ifosfamide. Following activation in the liver, ifosfamide interferes with dna through formation of phosphotriesters and dnadna crosslinks, thereby inhibiting protein synthesis and dna synthesis. Ifosfamide fda prescribing information, side effects and. Continuous infusion high dose ifosfamide at 1gmm2day over 14 days is highly active and well tolerated in a heavily pretreated cohort. Link to the pdf file there and select the pdf file, then ok. Two cases of fatal encephalopathy related to ifosfamide. How to insert a pdf into powerpoint online tech tips. Pubchemthe exact mechanism of ifosfamide has not been determined, but appears to be similar to other alkylating agents. Please click here for important safety information, including boxed warning regarding hepatic impairment, and click here 3 for full prescribing information.
Ifosfamide is an antineoplastic agent useful in the treatment of a wide range of cancers including sarcomas, gynecologic cancers, lymphoma and testicular cancers. Ifosfamide treatment as a 10day continuous intravenous. Ifosfamide is chemically related to the nitrogen mustards and is similar in chemical structure to cyclophosphamide. Ifosfamide fda prescribing information, side effects and uses. Find patient medical information for ifosfamide intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Ifosfamide is embryotoxic to rabbits receiving 88 mgm2day doses from the 6th through the 18th day. Ifosfamide treatment as a 10day continuous intravenous infusion. Idamycin idarubicin hydrochloride for injection, usp. This typically regresses after completing treatment. A comparative effectiveness study is warranted to compare costbenefit and patient preference between 14 day and 7 day regimens. Ifosfamide may cause neurotoxicity in 10% to 30% of treated patients.
The stability of ifosfamide in ringer lactate buffer solution either alone or. Ixempra ixabepilone dosing and administration guide. In cases of febrile neutropenia or grade 4 hematological toxicity, cisplatin, and ifosfamide doses were reduced by 20% for the further cycles. Ifosfamide is an alkylating agent that is fda approved for the treatment of germ cell testicular cancer. Cyclophosphamide and ifosfamide are widely used drugs for. The recommendations in this online publication do not indicate an exclusive course of treatment or serve as a standard of medical care. Ifex ifosfamide for injection, usp singledose vials for constitution and. Ifosfamide drug monograph pediatric care online aap. Ifosfamide is structurally related to cyclophosphamide and has been used in the treatment of a variety of solid tumors, including lung, testicular, and breast cancer. Aug, 2018 ifex ifosfamide for injection, usp singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. Continuous infusion high dose ifosfamide has shown efficacy and tolerability in pediatric patients with sarcoma. Open your powerpoint presentation on the page you want to insert the pdf within.